Two skin boosters that refresh dry, dull skin over a short course of sessions, improving hydration and the look of skin quality. Neither adds volume, and neither works overnight. You'll know the full cost before you start.
£400Profhilo, the full course of twoPolynucleotides: £600 for the course of three. £200 a session for either.
The numbers, up front
Profhilo or polynucleotides
The same questions for both, answered from the clinic's own protocol and prices.
| Profhilo | Polynucleotides | |
|---|---|---|
| What it is | Hyaluronic acid that isn't cross-linked, so it spreads through the skin rather than staying where it's placed. Not a filler. | A purified ingredient made from fish, usually salmon or trout, placed in the skin with fine injections. Not a filler. |
| What it's for | Hydration, for skin that has become dry or dull. | Skin quality, for skin that looks dull, uneven or crepey. |
| Areas | Lower face, neck, décolletage or hands. | Face and neck. |
| Under the eyes | No. It isn't placed directly under the eyes. | Yes, for thin or crepey skin there. It won't fill a hollow or remove a shadow caused by one. |
| Sessions in the course | Two | Three |
| Spacing | Four weeks apart | About three weeks apart |
| Each session | About 15 minutes | About 20 minutes |
| Straight after | Small raised bumps at each injection point, gone within a few hours. | Short-lived swelling at the injection points, and now and then a bruise. Most people are presentable the next day. |
| When to judge it | Six to eight weeks after the second session. Very little happens in the first two weeks. | Slowly, over the course. It won't give a fast result. |
| Maintenance | One session about every six months. Some people go longer. | One session every six to nine months. |
| Price | £200 a session. £400 for the course. | £200 a session. £600 for the course. |
| Year one | £600: the course, then one maintenance session about six months later. | £800: the course, then one maintenance session six to nine months later. |
| Not for you if | You want volume, or a line or hollow filled. | You have a fish allergy, or you want volume or a fast result. |
They aren't rivals, and they're often used together. Year-one figures are the prices above added up, with no discounts. If you can't tell which you need, that's what the free consultation is for.
Who it's for
For skin that has become dry or dull, most often from the late thirties onwards, on the lower face, neck, décolletage or hands. A good first injectable if you don't want to look treated.
For skin that looks dull, uneven or crepey, if you want it to look better with no change at all to the shape of your face.
They aren't rivals, and they're often used together. If you can't tell which you need, that's what the free consultation is for. Alicia will tell you which suits your skin, or if neither does.
Skin boosters are for skin quality, not skin conditions. If your skin is sore, inflamed or flaring, see your GP first.
How it works
A short, no-pressure call, within one working day, to answer your questions and book your free consultation.
Forty-five minutes, face to face, with Alicia. She looks at your skin and asks about your health and any allergies. Then she tells you which treatment suits you, or if neither does.
Profhilo: two sessions, four weeks apart, about fifteen minutes each. Polynucleotides: three sessions, about three weeks apart, about twenty minutes each.
Very little happens in the first two weeks. Judge Profhilo six to eight weeks after the second session. Polynucleotides work slowly, so judge them once the course is finished.
One £200 session about every six months for Profhilo, or every six to nine months for polynucleotides.
Straight after: small bumps where each injection went in, which settle within a few hours, and sometimes a bruise. Most people are presentable the next day. If you have an event coming up, mention it on the call so your sessions can be planned around it.
Before you decide
Price
£400Profhilo: the course of two
£600Polynucleotides: the course of three
We show course totals, not just the session price, because the session price on its own is misleading.
Request a call backWho'll treat you
Registered nurse · leads the clinic
A private treatment room at Glebe Farm, one client at a time.
Reviews
5.0
226 reviews
Reviews of Fill Good Aesthetics on Google, across all the clinic's treatments, as of October 2026. Fill Good Skin Booster is the clinic's Profhilo and polynucleotide service.
Would 100% recommend! Alicia took the time to talk to me about what I needed and was honest and kind, which is what you need when considering these kind of treatments. Alicia took the time to check in following treatments and put any worries I had to rest throughout the process.
Alicia was incredibly friendly and kind from the moment I arrived for my first appointment. She made me feel completely comfortable and at ease, taking the time to explain everything clearly and answer all of my questions. I’m so happy with the experience and would highly recommend Alicia to anyone considering treatment for the first time.
Always a pleasant experience, very knowledgable and friendly. Always explains the treatment and after care in detail and ensures you are comfortable at all times. Highly recommend and I’m excited to try other treatments.
Alicia is a beautiful person inside & out. I was made a easy & Alicia talked me through the treatment & what to expect.Clinic is so welcoming.Would highly recommend.
A selection from Google, quoted with each reviewer's permission. None of them names Profhilo or polynucleotides.
Questions
Usually Profhilo if your skin has become dry or dull across the face, neck or hands. Usually polynucleotides if it looks crepey or uneven. If you're not sure, that's what the free consultation is for, and Alicia will also tell you if neither is the answer.
No. Profhilo is hyaluronic acid that isn't cross-linked, so it spreads through the skin instead of holding a shape where it's placed. Polynucleotides add no volume either. Neither will fill a line or change the shape of your face.
Slowly. With Profhilo, very little happens in the first two weeks. Hydration comes first, and you judge it six to eight weeks after the second session, more often in photos and in how make-up sits than in the mirror one morning. Polynucleotides work gradually over the course, so judge them once it's finished, not between sessions.
We'd rather tell you about maintenance than promise a length of time. After the course, most people have one Profhilo session about every six months, and some go longer. For polynucleotides it's one session every six to nine months.
Polynucleotides, yes: they can be used under the eyes for thin or crepey skin. Profhilo, no: it isn't placed directly under the eyes. Neither will fill a hollow or remove a shadow caused by one, and Alicia will tell you at the consultation if that's what you're seeing.
You'll feel each small injection, and how that feels varies from person to person. Alicia talks you through what to expect at the consultation, and you can ask for a pause at any point.
You might. Profhilo leaves small raised bumps at each injection point that settle within a few hours. Polynucleotides cause short-lived swelling and, now and then, a bruise. Most people are presentable the next day. If you have an event coming up, say so on the call and your sessions can be planned around it.
Yes. They're often used together rather than one instead of the other. Alicia plans the order and spacing with you at the consultation, and each session is £200.
Profhilo: £400 for the course, then one £200 maintenance session about six months later, so £600. Polynucleotides: £600 for the course and one £200 maintenance session, so £800. That's the prices above added up.
A purified ingredient taken from fish, usually salmon or trout. That's why they aren't suitable if you have a fish allergy. Tell Alicia about any allergies at your consultation.
Alicia Marsland, every session. She's a registered nurse with seventeen years in clinical practice.
Yes. You must be 18 or over, with no exceptions.
Free consultation
Takes a minute. One of the team calls you back to answer your questions and, if you'd like, book your free consultation with Alicia.
Getting here
Private treatment rooms on a farm between Spalding and Boston, with free parking outside.
Glebe Farm, Church EndApproximate driving times from each town centre, in normal traffic, checked against a route planner.
